Discontinuity and failures of therapy with bisphosphonates: joint assessment of predictors with multi-state models


Data from a cohort of women treated with bisphosphonates were usedto illustrate that multi-state models may be the useful tools ofanalysis where two causes of treatment failure are the ultimate outcomeof interest, and the sequence of recurrent episodes of treatmentstarting and discontinuing is also of concern.

Pharmacoepidemiology and Drug Safety
Gianluca Baio
Gianluca Baio
Professor of Statistics and Health Economics